Systematic review of behavioural change theory in the context of TBS for respiratory and allergic airways disease

The aim of this study is to examine published literature AND/OR available solutions from a communication and behavioral perspective to identify the content and format of the intervention delivered and to investigate the relationships between these characteristics and intervention success (defined in terms of user satisfaction, behavior change and health outcomes).

Lead Investigator:
Alex Dima, John Blakey
Research Team:
Status: Proposed Study, Seeking Funding
Support: 
Registration: 
Documents and Publications:
Protocol
Abstracts
Presentations
Final Publications
Additional Material

Guidance to standardise the development of TBS with utility for respiratory and allergic airway diseases

The aim of this study is to develop more didactic recommendations around the development of Apps and technologies that would provide practical support and guidance to developers and clinicians so that they can meet the WHO standards for publication / reporting of technologies. Longer term, there would be an intention to provide Intermittent updates to the recommendations / checklist as the field continues to evolve.

Lead Investigator:
John Blakey
Research Team:
Status: Proposed Study, Seeking Funding
Support:
Registration: 
Documents and Publications:
Protocol
Abstracts
Presentations
Final Publications
Additional Material

Identify and prioirtise multi-stakeholder end-user needs for TBS in respiratory and allergic airway disease

The aim of this project is to develop a series of end user specific checklists to guide developers in their creation of meaningful and relevant respiratory technologies.

Lead Investigator:
John Blakey, Richard Costello
Research Team:
Alexandra Dima, Jerry Krishnan; Ron Dandurand; David Price; Dermot Ryan; Alison Chisholm

Status: Proposed Study, Seeking Funding
Support:
Registration:
Documents and Publications:

Protocol
Abstracts
Presentations
Final Publications
Additional Material

Validation of multi-dimensional indices (ADO, DOSE) and GOLD categorisation in routine care patients with COPD

Global Obstructive Lung Disease (GOLD) categories for chronic obstructive pulmonary disease (COPD) are recommended for severity assessment in clinical care. There is a need to understand their value in routine clinical settings and compare them with other multidimensional assessment measures.

An observational cohort study using databases comprising 5486 primary care COPD patients from UK Sweden, and Holland.

The GOLD categories, DOSE and ADO indices, associations with (i) current health status measured by the CCQ and SGRQ; exacerbations and hospital admissions and (ii) future exacerbations, admissions and mortality. The distribution into GOLD categories and future risk associated with the categories.

Lead Investigator:
Dr Rupert Jones
Research Team:
David Price, Niels H. Chavannes, Amanda Lee, Björn Ställberg, Karin Lisspers, Josefin Sundh and Michael Hyland.
On behalf of the UNLOCK group of the IPCRG.

Status: Active Study
Support: Respiratory Effectiveness Group, UNLOCK Group of the IPCRG
Registration: 
Documents and Publications:
Protocol
Abstracts
Presentations
Final Publications:
Primary Care Respiratory Medicine
Additional Material

Validation of the Concept of Control of COPD in Clinical Practice

The primary aims of this multicenter, observational longitudinal study are to:

  • Identify the degree of control in an international cohort of unselected COPD patients
  • Compare the outcomes of controlled versus uncontrolled patients after one year follow-up

The study will also:

  • Compare the clinical variables with CAT and CCQ as tool to identify impact and stability in COPD
  • Identify differences in degree of control according to adequacy of treatment to current guidelines
  • Identify demographic and clinical characteristics associated with poor control of COPD

Lead Investigator:
Marc Miravitlles
Research Team:
Alison Chisholm Anjan Nibber

Status: Active Study
Support: Novartis
Registration: ENCEPP/SDPP/10697
Documents and Publications:
Protocol
Abstracts
Presentations
Final Publications
Additional Material

Validate outcome definitions and methodologies use in observational asthma research

The aim of this study is to validate a series of objective asthma control measures that have been used in published real-life respiratory research. The outcome measures will be compared and contrasted to patient-reported outcomes and/or gold-standard, validated asthma control tools and measures (as appropriate). Where possible, their validity, responsiveness and predictive value will also be assessed and a rank order of outcomes (and possibly hierarchical modelling) will be established to aid in appropriate outcome selection for future studies.

Lead Investigator:
Richard Martin
Research Team:
David Price, Alex Dima, Alan Kaplan, Gene Colice, Todor Popov, Janet Holbrook, Emilio Pizzichini, Nikos Papadopoulos, Guy Brusselle, Helen Reddel, Professor David Price, Julie von Ziegenweidt, Annie Burden, Vicky Thomas, Muzammil Ali, Liz Hillyer.

Status: Active Study
Support: Respiratory Effectiveness Group
Registration: ENCePP: ENCEPP/SDPP/4860
Documents and Publications:
Protocol
Abstracts
Presentations
Final Publications
Additional Material

Develop (implementable) tools to facilitate quality appraisal of published real-world evidence

Assess the quality of the asthma comparative effectiveness literature to identify evidence for consideration by future guideline developers

Evaluation and validation of oscillometry in terms of clinical value and reliability in routine patient care

The REG / EAACI Taskforce aims to conduct a systematic critical review of the real-life asthma literature between 2009–13 and write a report describing the current quality of real-life research in asthma; highlighting studies worthy of possible integration into asthma-related guidelines and policy decisions, and recommending quality targets for the future.

The critical appraisal of the evidence will involve the following core components:

Based on a review of published quality standards (e.g. extended CONSORT, STROBE, REG quality standards, etc), quality checklists and scoring tools for pragmatic trials and observational studies will be developed.
Identification of real-life asthma studies published in peer review journals during the last 5 years (2009–13), and of the main research question(s) addressed in these studies.
Categorization of published studies using the proposed REG framework (in press with the Lancet Respiratory Medicine), i.e., in terms of the extent to which their (a) study population and (b) management approach reflect real-life. Based on their position within the REG framework, identification of the relevant quality appraisal tools to assess the quality of the categorized studies.
Application of the relevant assessment tools and taskforce’s quality scoring tool, resulting in up- or down-grading of the level of evidence provided by these studies on the considered research question(s).
Comparison of populations, settings, characteristics of care and results between selected high-quality real-life studies and RCTs addressing the same research question(s).
Identification of areas where real-life asthma research could add to RCTs’ results.
Synthesis and publication of the findings, with special interest on where and how the evidence retrieved from real-life research complements evidence from RCTs and could, therefore, be considered when developing guidelines.
Lead Investigator:
Nicolas Roche.
Research Team:
David Price, Nikos Papadopoulos, Leif Bjermer, Dermot Ryan, Helen Reddel, Maarten van den Berge, Guy Brusselle, John Haughney, Mike Thomas, Marc MIravitlles, Eric van Ganse, Jerry Krishnan
Status: Active Study
Support: EAACI
Registration:
Documents and Publications:
Protocol
Abstracts
Presentations
Final Publications
Additional Material

Assess the quality of the asthma comparative effectiveness literature to identify evidence for consideration by future guideline developers

The REG / EAACI  Taskforce aims to conduct a systematic critical review of the real-life asthma literature between 2009–13 and write a report describing the current quality of real-life research in asthma; highlighting studies worthy of possible integration into asthma-related guidelines and policy decisions, and recommending quality targets for the future.

The critical appraisal of the evidence will involve the following core components:

  • Based on a review of published quality standards (e.g. extended CONSORT, STROBE, REG quality standards, etc), quality checklists and scoring tools for pragmatic trials and observational studies will be developed.
  • Identification of real-life asthma studies published in peer review journals during the last 5 years (2009–13), and of the main research question(s) addressed in these studies.
  • Categorization of published studies using the proposed REG framework (in press with the Lancet Respiratory Medicine), i.e., in terms of the extent to which their (a) study population and (b) management approach reflect real-life. Based on their position within the REG framework, identification of the relevant quality appraisal tools to assess the quality of the categorized studies.
  • Application of the relevant assessment tools and taskforce’s quality scoring tool, resulting in up- or down-grading of the level of evidence provided by these studies on the considered research question(s).
  • Comparison of populations, settings, characteristics of care and results between selected high-quality real-life studies and RCTs addressing the same research question(s).
  • Identification of areas where real-life asthma research could add to RCTs’ results.
  • Synthesis and publication of the findings, with special interest on where and how the evidence retrieved from real-life research complements evidence from RCTs and could, therefore, be considered when developing guidelines.

Lead Investigator:
Nicolas Roche.
Research Team:
David Price, Nikos Papadopoulos, Leif Bjermer, Dermot Ryan, Helen Reddel, Maarten van den Berge, Guy Brusselle, John Haughney, Mike Thomas, Marc MIravitlles, Eric van Ganse, Jerry Krishnan
Status: Active Study
Support: EAACI
Registration: 
Documents and Publications:
Protocol
Abstracts
Presentations
Final Publications
Additional Material

Provide recommendations and tools to help inform the design and quality appraisal of databases for observational research in respiratory and allergic airways disease

The aim of this study is to develop a checklist with optimum and minimum reporting items of respiratory databases and establish a repository in which the characteristics of existing respiratory databases, reported in a standard way using the new checklist, can be stored and accessed.
Lead Investigator:
Katia Verhamme
Research Team:
Job van Boven, Jon Campbell, Niels Chavannes, David Price, Alison Chisholm

 

Status: Proposed Study
Support:
Registration:
Documents and Publications:
Protocol
Abstracts
Presentations
Final Publications
Additional Material

 

 

Evaluate the burden of allergic disease study from multi-stakeholder (primary care, secondary care, pharmacy) perspectives

Rationale: a substantial proportion of patients with allergic disease do not present in primary care; instead purchase OTC therapies from the pharmacy. To understand the true burden of allergic disease there is a need to evaluate the burden of allergic disease presenting in the pharmacy setting as well as in clinical practice.
Aim:

  • Improve understanding of the true burden of allergic disease
  • Gain evidence to inform improved consumer guidance in the future

Study approach:

  • Questionnaire based study within the pharmacy setting
  • Target a large patient/buyer group with standardised survey questions
  • Collect data digitally (i.e. via computer or iPad ± use of patient incentives)

Lead Investigator:
Dermot Ryan, Sinthia Bosnic-Anticevich, Aji Barot

Research Team:
Status: Proposed Study
Support: 
Registration: 
Documents and Publications:
Protocol
Abstracts
Presentations
Final Publications
Additional Material