Comparative effectiveness of extrafine particle versus guideline recommended alternatives as first- and step-up maintenance therapy in children

Because randomized controlled trials of established pediatric asthma therapies are expensive and difficult to perform, observational studies may fill gaps in the evidence base. The aim of this study was to compare the effectiveness of representative small-particle inhaled corticosteroid (ICS) with that of standard sizeeparticle ICS for children initiating or stepping up ICS therapy for asthma (analysis 1) and to compare the effectiveness of ICS dose step-up using small-particle ICS with adding longacting b2-agonist (LABA) to the ICS.

Lead Investigator:
Willem M.C. van Aalderen, MD, PhD
Research Team:
Jonathan Grigg, MD
Theresa W. Guilbert, MD, MSc
Nicolas Roche, MD, PhD
Elliot Israel, MD
Richard J. Martin, MD
Gene Colice, MD
Dirkje S. Postma, MD, PhD
Elizabeth V. Hillyer, DVM
Anne Burden, MSc
Victoria Thomas, MSc
Julie von Ziegenweidt
David Price, FRCGP
Status: Completed Study
Support: Teva
Documents and Publications:
Final Publication
Additional Material: Letter of Support