Development of a Longitudinal Asthma Treatment Step Algorithm and Association with Asthma Outcomes

Objective 1.a Based on asthma management guidelines (British Thoracic Society and Global Initiative for Asthma), we will develop pharmacy utilization treatment step algorithms using a quality controlled, primary care research database from the United Kingdom.
Objective 1.b We will examine longitudinal pharmacy utilization treatment step patterns and associate them with patient characteristics.
From Objective 1, we will be able to characterize patients within a large-scale primary care research database in terms of their asthma management guideline-based treatment step, track how patients’ treatment steps change over time, and relate treatment steps and changes to various patient characteristics.
Objective 2. Within age categories, we will compare asthma outcomes by treatment step utilization patterns.
From Objective 2, we will be able to test for differences in the likelihood of achieving asthma control and the risk of exacerbation by commonly observed treatment step patterns, adjusting for differences in patient characteristics across patterns. For example, is the likelihood of control higher for those who have a longer history of a stable treatment step as compared to those who are consistently stepping up or down? Is the likelihood of control or exacerbation modified by treatment step?

Lead Investigators:
Jon Campbell
Alexandra Dima
Research Team:
Status: Proposed Study, Seeking Funding
Documents and Publications:
Final Publications
Additional Material