Mike Thomas, University of Southampton, UK.
The research team will be made up of an international group of leading respiratory researchers, all members of the Respiratory Effectiveness Group.
- Ian Pavord, UK
- Alan Kaplan, Canada
- Dirkje Postma, The Netherlands
- David Price, UK
- Cindy Rand, USA
- Gene Colice, USA
- Alberto Papi, Italy
- John Blakey, UK
- Lynn Josephs, UK
- Todor Popov, Bulgaria
- Janet Holbrook, USA
- Hilary Pinnock, UK
- Iain Small, UK
- Emillio Pizzichini, Brazil
- Alex Dima, Netherlands
- Vibeke Backer, Denmark
- Samantha Walker, UK
- Borislav Dimitrov, UK
The study is co-sponsored by the Respiratory Effectiveness Group (data analysis and publication) and by Research in Real Life (data provision)
Approved by the Annonymised Data Ethics and Transparency (ADEPT) Committee (ref. protocol 2.7)
Registered on the European Medicines Agency’s ENCePP E-registry, reference ENCEPP/SDPP/4869
- Hypothesis: Some asthma patients experience multiple exacerbations, which are associated with an impact on health-related quality of life and prognosis. It may be possible to identify these patients using routine data collected in primary care.
- To undertake a descriptive analysis of longitudinal patient data. Prescribed oral steroid courses will be mapped for all asthma patients over a 5-year period.
- Investigation of individual patient characteristics associated with the frequent (and also infrequent) asthma exacerbation phenotype (vs controls)
- Multivariate modelling to weight individual characteristics and identify a possible composite group of characteristics strongly associated with frequent (and infrequent) asthma exacerbations (that could be used to inform a clinical decision support tool)