Mike Thomas, University of Southampton, UK.
The research team will be made up of an international group of leading respiratory researchers, all members of the Respiratory Effectiveness Group.
- Ian Pavord, UK
- Alan Kaplan, Canada
- Dirkje Postma, The Netherlands
- David Price, UK
- Cindy Rand, USA
- Gene Colice, USA
- Alberto Papi, Italy
- John Blakey, UK
- Lynn Josephs, UK
- Todor Popov, Bulgaria
- Janet Holbrook, USA
- Hilary Pinnock, UK
- Iain Small, UK
- Emillio Pizzichini, Brazil
- Alex Dima, Netherlands
- Vibeke Backer, Denmark
- Samantha Walker, UK
- Borislav Dimitrov, UK
The study is co-sponsored by the Respiratory Effectiveness Group (data analysis and publication) and by Research in Real Life (data provision)Ethical approval:
Approved by the Annonymised Data Ethics and Transparency (ADEPT) Committee (ref. protocol 2.7)
Registered on the European Medicines Agency’s ENCePP E-registry, reference ENCEPP/SDPP/4869
- Hypothesis: Some asthma patients experience multiple exacerbations, which are associated with an impact on health-related quality of life and prognosis. It may be possible to identify these patients using routine data collected in primary care.
- To undertake a descriptive analysis of longitudinal patient data. Prescribed oral steroid courses will be mapped for all asthma patients over a 5-year period.
- Investigation of individual patient characteristics associated with the frequent (and also infrequent) asthma exacerbation phenotype (vs controls)
- Multivariate modelling to weight individual characteristics and identify a possible composite group of characteristics strongly associated with frequent (and infrequent) asthma exacerbations (that could be used to inform a clinical decision support tool)
Documents and Publications