EF- vs Standard-Particle ICS – A Systematic Review

Lead Investigator

Dirkje Postma: Department of Pulmonary Medicine University Medical Center Groningen University of Groningen, The Netherlands

Research Team

Richard Martin: Department of Medicine, National Jewish Health, Denver, CO, USA and Chair of the REG SASG Working Group.

David Price: Centre of Academic Primary Care, University of Aberdeen, Aberdeen, UK

Elliot Israel: Pulmonary Clinical Research, Brigham and Women’s Hospital and Harvard Medical School, Bostonicolas Roche: Pneumologie et Reanimation, Hotel-Dieu, AP-HP, University of Paris Descartes, Paris, Franceheresa Guilbert (Steering committee)

Wim van Aalderen: Department of Pediatric Respiratory Disease and Allergy, Emma Children’s Hospital AMC, Amsterdam, The Netherlands

Jonathan Grigg: Blizard Institute, Queen Mary, University of London, London, UK

Alberto Papi: Respiratory Medicine and Director of the Section of Respiratory Diseases of the Department of Clinical And Experimental Medicine of the University of Ferrara at S.Anna University Hospital, Ferrara, Italy

Wanda Phipatanakul: Specialist in Allergy Immunology at Boston Children’s Hospital, Boston, MA, USA

Akki Niimi: Department of Medical Oncology and Immunology, Nagoya City University Graduate School of Medical Sciences, and Head of Respiratory Medicine, Nagoya City University Hospital, Nagoya

Alan Kaplan: Respiratory Medicine Special Interest Focus Group Chair of the College of Family Physicians of Canada

Caroline Gourder: Department of Medicine, Mater Dei Hospital, Msida, Malta

Emilio Pizzichini: Department of Pulmonology, the Universidade Federal de Santa Catarina – UFSC, Federal University of Santa Catarina – School of Medicine, Florianópolis, Brazil

Hironori Sagara:  Division of Allergology and Respiratory Medicine,  Showa University School of Medicine, Tokyo

Nicolas Roche: Hôtel-Dieu Hospital by University Paris Descartes, Paris

Omar Usman: National Heart and Lung Institute (NHLI), Imperial College London and Royal Brompton Hospital, London, UK

Theresa Guilbert: Department of Pediatrics, University of Wisconsin-Madison School of Medicine and Public Health, Madison, USA

 

Marjan Kerkhof: Researcher and Epidemiologist, Research in Real Life Ltd, Cambridge, UK

Anjan Nibber: Researcher, Research in Real Life Ltd, Cambridge, UK

Alison Chisholm: REG Chief Scientific Officer

Status: Active

Support:

Chiesi

Registration

Short Description

The aim of the study is to summarise the comparative effectiveness of ICS medications of different particle sizes as assessed in real-life studies and to compare real-life effectiveness and safety outcomes to the RCT systematic review of the efficacy and safety outcomes. Through comparison of the real-life and RCT data, key similarities and differences in the data will be drawn out and discussed, and argument presented for any apparent contradictions in the data. These arguments will focus specifically on the inherent differences in original research questions being addressed by the respective studies and the resultant implication for the interpretation of the evidence so produced.

Documents and Publications

  • Protocol
  • Abstracts
  • Presentations
  • Final Publications
  • Additional Material