Study & Trial registration

 

Why is this important?

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As the All Trials Registered | All Results Reported campaign warns:

Around half of all clinical trials have not been published; some trials have not even been registered. If action is not taken urgently, information on what was done and what was found in trials could be lost forever, leading to bad treatment decisions, missed opportunities for good medicine, and trials being repeated unnecessarily.

The AllTrials campaign was launched in January 2013 as a joint initiative between Bad Science, Sense About ScienceBMJ, James Lind Initiative and the Centre for Evidence -based Medicine. It calls on responsible bodies to ensure that all trials past and present, for all treatments, are registered; and that the full methods and the results are reported.[/two_third]

[one_third_last][custom_frame_left]AllTrials logo[/custom_frame_left][/one_third_last]
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All for one and one rule for all!

REG supports the All Trials Registered | All Results Reported campaign  and believes these standards should be applied to real-life studies (observational studies using clinical and administrative databases as well as pragmatic trials).

As an European Network of Centres for Pharmacoepidemiology and Pharmacovigilance (ENCePP®) network, REG registers its own funded research and promotes use of the ENCePP E-registry, which aims to:

  • Increase transparency
  • Reduce publication bias
  • Promote information exchange
  • Facilitate collaborations within the scientific community.
  • Facilitate optimal use of pharmacoepidemiology and pharmacovigilance expertise by preventing unnecessary duplication of research
  • Increase transparency
  • Reduce publication bias
  • Promote information exchange
  • Facilitate collaborations within the scientific community.
  • Facilitate optimal use of pharmacoepidemiology and pharmacovigilance expertise by preventing unnecessary duplication of research.

Applying this form of pre-planning and registration to real-life studies, means they will mirror (more closely) the registration requirements asked of prospective randomised clinical trials and should help  shake-off connotations associated with “mining” real-life data retrospectively to find outcomes of significance. The result is the conductance of more ethically-transparent and well-planned studies.
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Other existing trial registries

A number of trial registries exist, primarily designed to facilitate the registration of classical randomised controlled trials:

[one_half]• ClinicalTrials.gov
• Current Controlled Trials
• Australian New Zealand Clinical Trials Registry (ANZCTR)
• Brazilian Clinical Trials Registry (ReBec)
• Chinese Clinical Trial Registry (ChiCTR)
• Clinical Research Information Service (CRiS), Republic of Korea
• 
EU Clinical Trials Register (EU-CTR)
• German Clinical Trials Register (DRKS)

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• Iranian Registry of Clinical Trials (IRCT)
• 
ISRCTN.org
• Japan Primary Registries Network (JPRN)
• The Netherlands National Trial Register (NTR)
• Pan African Clinical Trial Registry (PACTR)
• Sri Lanka Clinical Trials Registry (SLCTR)
• Clinical Trials Registry – India (CTRI)
• Cuban Public Registry of Clinical Trials (RPCEC)

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