The primary aim of the proposed study is to explore the relationship between blood eosinophil count and future exacerbation risk in COPD and effect of preventative COPD therapy on eosinophil level. Additional analysis will also aim to investigate the stability of the phenotype, defined by change in eosinophils over time and in response to treatment.
Exploratory investigations will also seek to characterise features of COPD patients with eosinophilia in terms of their COPD stage and categorisation, comorbid conditions and other clinical characteristics (respiratory symptoms, past history of exacerbations, risk factors).
This study will be the first in a series of REG-funded studies designed to explore the relationship between blood eosinophil count, COPD disease status, COPD exacerbations and to explore its value and utility as a measureable marker of future risk in COPD.
In particular, this study aims to:
- Establish the relationship between blood eosinophil count and:
o Future COPD exacerbations.
o Response to preventative COPD therapy; and
- Investigate the stability of the phenotype, defined by change in eosinophils over time and in response to treatment.
Dirkje S. Postma