Adherence Working Group


  • Alex Dima - Lead
  • Patrick Souverein
  • Job van Boven
  • Ellen Koster
  • Marcia Vervloet
  • Eric Van Ganse
  • Aji Barot
  • Marijn de Bruin
  • G Walter Canonica
  • Sinthia Bosnic-Anticevich


The latest Adherence meeting took place at the REG Summit 2018 in Amsterdam.

Adherence REG Summit 2018

Work Plan

The current focus of the Adherence Study Working Group, initiated under the leadership of Gene Colice and with Alex Dima as the current research lead for the group, is a longitudinal observational study designed to better understand the bidirectional relationship between ICS adherence and asthma control. The study was motivated by the understanding that high adherence is not always associated with well-controlled disease and that low adherence does not always result in poorly-controlled asthma – patients may down-titrate their prescribed medication during periods of less severe disease. The study draws on 3 years’ of UK prescribing data (1 baseline; 2 outcome) and has been underway for ~1 year. The analysis is being carried out by a team working across three centres in The Netherlands (Alex Dima, Patrick Souverein, Marcia Vervloet and Ellen Koster). The first (feasibility) phase of the study is now complete. Phase 1. This phase assessed the number of eligible patients and patterns of adherence, using a variety of different database proxy measures of adherence over 6-, 8-, 12 and 24-month evaluation periods, to inform Phase II. Sufficient within-patient and between-patient variation has been identified to support the planned longitudinal analysis.

The Group is also looking at developing an “adherence road map” to identify research needs and opportunities and hopes to organise a one-day meeting of adherence experts to feed into this.

Working Group Documents

Click here to access files available from the Adherence Working Group