Adherence Working Group


  • Alex Dima - Lead
  • Aileen David-Wang
  • Aji Barot
  • Bernard Vrijens
  • Camilo Roa
  • Dermot Ryan
  • Ellen Koster
  • Eric van Ganse
  • Gene Colice
  • Juliet Foster
  • Job van Boven
  • Marcia Vervloet
  • Marijn de Bruin
  • Michelle Nuttal Eakin
  • Nina Castillo-Carandang
  • Patrick Souverein
  • Richard Costello
  • Thys van der Molen


The latest Adherence meeting took place at the REG Summit 2018 in Amsterdam.

Adherence REG Summit 2018


Work Plan

The current focus of the Adherence Study Working Group, initiated under the leadership of Gene Colice and with Alex Dima as the current research lead for the group, is a longitudinal observational study designed to better understand the bidirectional relationship between ICS adherence and asthma control. The study was motivated by the understanding that high adherence is not always associated with well-controlled disease and that low adherence does not always result in poorly-controlled asthma – patients may down-titrate their prescribed medication during periods of less severe disease. The study draws on 3 years’ of UK prescribing data (1 baseline; 2 outcome) and has been underway for ~1 year. The analysis is being carried out by a team working across three centres in The Netherlands (Alex Dima, Patrick Souverein, Marcia Vervloet and Ellen Koster). The first (feasibility) phase of the study is now complete. Phase 1. This phase assessed the number of eligible patients and patterns of adherence, using a variety of different database proxy measures of adherence over 6-, 8-, 12 and 24-month evaluation periods, to inform Phase II. Sufficient within-patient and between-patient variation has been identified to support the planned longitudinal analysis.

The Group is also looking at developing an “adherence road map” to identify research needs and opportunities and hopes to organise a one-day meeting of adherence experts to feed into this.


Planned Studies, Seeking Funding

Utilise pharmacy dispensing data to validate primary care prescribing estimates of medication adherence behaviours

Active Studies:

Improve understanding of the bi-directional causality relationship between asthma outcomes and adherence


JACI: In Practice Special Issue: Respiratory Medication Adherence

Working Group Documents

Click here to access files available to members of the Adherence Working Group