Child Health Working Group

Child Health Working Group

Child Health Working Group


  • Steve Turner (Lead)
  • Alan Kaplan
  • Stanley Szefler
  • Nikos Papadopoulos
  • Wanda Phipatanakul
  • Theresa Guilbert
  • Teoh Oon Hoe
  • James Y. Paton
  • Clare Murray



The last meeting of the Child Health Working Group took place in Amsterdam during the REG Summit 2018

Child Health REG Summit 2018

Work Plan

The Child Health Working Group is one of REG’s original working groups. One of the initial studies that REG funded was comparative effectiveness evaluation of paediatric step-up therapies in routine clinical practice.

The study was set up off the back of the UK-government funded MASCOT study that aimed to evaluate the comparative effectiveness of different paediatric step-up options, but which struggled to recruit because the majority of children in the trial centres had already had their treatment optimised – a different study approach (one using real-life observational data) was required.

A paper describing the characteristics of patients prescribed different step-up (and possible motivators for step-up choice) has already been submitted for publication. Also in development are two outcome papers from the study – one looking at the comparative effectiveness over one year of (matched patients) stepping up from ICS to higher dose ICS

A further study using the same study population to explore predictors of asthma exacerbation in children is also in progress.

A recent research need, discussed in Rotterdam, is the need to compare outcomes in under 5s after treatment with oral steroids vs antibiotics. To further this line of inquiry, the group has submitted an outline application for research funding to the UK's British Lung Foundation.


Completed Studies:

Comparative effectiveness of Step three treatment options in children with asthma

Long-Acting β-Agonist in Combination or Separate Inhaler as Step-Up Therapy for Children with Uncontrolled Asthma Receiving Inhaled Corticosteroids.

Active Studies:

Clinical implications of combining antibiotics with usual care (oral steroids) for the management of asthma exacerbations

Comparative effectiveness of guideline recommended treatment options for patients with pre-school asthma / wheeze

Planned Studies

Investigate bronchiolitis in early childhood as a predictor of future and asthma

Working Group Documents

File Sharing

Click here to access files available to members of the Child Health Working Group