- Steve Turner (Lead)
- Alan Kaplan
- Stanley Szefler
- Wanda Phipatanakul
- Theresa Guilbert
- Teoh Oon Hoe
- James Y. Paton
- Clare Murray
- Nikos Papadopoulos
The last meeting of the Child Health Working Group took place in Amsterdam during the REG Summit 2018
The Child Health Working Group is one of REG’s original working groups. One of the initial studies that REG funded was comparative effectiveness evaluation of paediatric step-up therapies in routine clinical practice.
The study was set up off the back of the UK-government funded MASCOT study that aimed to evaluate the comparative effectiveness of different paediatric step-up options, but which struggled to recruit because the majority of children in the trial centres had already had their treatment optimised – a different study approach (one using real-life observational data) was required.
A paper describing the characteristics of patients prescribed different step-up (and possible motivators for step-up choice) has already been submitted for publication. Also in development are two outcome papers from the study – one looking at the comparative effectiveness over one year of (matched patients) stepping up from ICS to higher dose ICS
or to ICS+LABA, FDC ICS/LABA or ICS+LTRA.
A further study using the same study population to explore predictors of asthma exacerbation in children is also in progress.
A recent research need, discussed in Rotterdam, is the need to compare outcomes in under 5s after treatment with oral steroids vs antibiotics. To further this line of inquiry, the group has submitted an outline application for research funding to the UK's British Lung Foundation.
Working Group Documents